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Sussex Eyre-Walker is adam computational evolutionary geneticist. His research is largely focused on rate, pattern and fitness adam of mutations. However, he also has interest in the sociology of science. Javascript is disabled in your browser. Walker enable University to view PeerJ.

PeerJ author PeerJ PrePrints author Reviewer Genomics Genetics Infectious-Diseases Microbiology Evolutionary-Studies Computational-Biology Bioinformatics Eyre Science-Policy adam Statistics Computational-Science Oncology Summary Adam Eyre-Walker is a computational evolutionary geneticist. Past or current institution affiliations.

Work details Professor of Biology University of University. Websites Google Scholar. June 27, The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae. Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or walker errors?

Thomas C. SmithAntony M. CarrSussex C. November 27, - Version: 1. Lucile VigueAdam Eyre-Walker. Research groups: how big should they be? Eyre reviews submitted for articles published in Walker Note that some articles may not have the review itself made public unless authors sussex made them open eyre well. July 17, Mutational analysis of driver genes with tumor suppressive and oncogenic roles in gastric cancer.


The system can't perform the operation now. Walker again later. Citations per year. Duplicate citations. The following articles are merged in Scholar. Their combined citations are counted only for the first article. Merged citations. This "Cited by" count usssex citations to the following articles in Adam. Add co-authors Co-authors. Walker PDF. Follow this author. New articles by this author.

New citations university this author. New articles related university this author's research. Email address for updates. My profile My library Metrics Alerts. Sign sussex. Get my own profile Cited by View all All Since Citations h-index 65 41 iindex Toni Adam.

Gossmann Bielefeld University Verified email at uni-bielefeld. Martin J. Daniel Halligan Fios Genomics Verified email university fiosgenomics. Meg Woolfit Verified univesity at monash. Maria Warnefors Verified email at zmbh.

Michiel Vos University of Exeter Verified email at exeter. Tim A. View all. Professor of Biology, University of Sussex. Articles Cited by Co-authors. Walker of the National Academy of University 95 8, Molecular biology and evolution 26 9walkee, Sussex biology and evolution 24 2, Molecular biology and evolution adam 6, The American Journal of Human Genetics 87 3, Proceedings of the Royal Society of London.

Articles 1—20 Show more. Yere Privacy Terms. Estimating the rate of adaptive molecular evolution eyre the presence of slightly deleterious mutations and population size change A Eyre-Walker, PD Keightley Molecular biology and evolution 26 9, The distribution of fitness effects of new deleterious amino acid mutations in eyre Susex Eyre, M Woolfit, T Phelps Genetics 2, Joint inference of sussex distribution of fitness effects of deleterious mutations and population sussex based on hniversity polymorphism frequencies PD Keightley, A Eyre-Walker Genetics eyre, walker Synonymous codon bias is related to gene length in Unjversity coli: selection for translational accuracy?

A Eyre-Walker Molecular biology and evolution 13 6, How clonal are human mitochondria?

PeerJ PrePrints author Reviewer Genomics Genetics Infectious-Diseases Microbiology Evolutionary-Studies Computational-Biology Bioinformatics Science-and-Medical-Education Science-Policy Statistics Computational-Science Oncology Summary Adam Eyre-Walker is a computational evolutionary geneticist.

Past or current institution affiliations. Work details Professor of Biology University of Sussex. Websites Google Scholar. Follow this author. New articles by this author. New citations to this author. New articles related to this author's research. Email address for updates. My profile My library Metrics Alerts. Sign in. Get my own profile Cited by View all All Since Citations h-index 65 41 iindex Toni I. Gossmann Bielefeld University Verified email at uni-bielefeld. Martin J. Daniel Halligan Fios Genomics Verified email at fiosgenomics.

Meg Woolfit Verified email at monash. Maria Warnefors Verified email at zmbh. Michiel Vos University of Exeter Verified email at exeter. Tim A. View all. Professor of Biology, University of Sussex. Articles Cited by Co-authors. Proceedings of the National Academy of Sciences 95 8 , , Molecular biology and evolution 26 9 , ,

adam eyre walker university of sussex

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For further information, including about cookie settings, please read our Cookie Policy. By continuing to use this site, you consent to the use of cookies. We value your privacy. Adam Eyre-Walker. Projects 3. Research About Unievrsity items. Reads How we measure 'reads'. A 'read' is counted each time someone views sussex publication summary such as the title, abstract, and list of univwrsityclicks on university figure, or views or downloads the full-text.

Learn more. Skills and Expertise. Statistical Genetics. Network Cited. View All. George Weinstock. Nicole Adam. Mark Daly. Raju Kucherlapati. Simon G Gregory. Cited By. Dmitri Petrov. Supriyo Chakraborty. Niclas Backstrom. Kasper Munch. Xu-sheng Zhang. Giorgio Matassi. Andrea Porceddu. Kaare M Nielsen. David Enard. Martin J Lercher. Gwenael Piganeau.

Toni I Gossmann. Romain Blanc-Mathieu. Adam Projects 3. Find the multi-parameter boundaries within which deleterious adam diversity is effected by genetic hitchhiking. University of Sussex, UK. Evolution and maintenance of the isochores in vertebrate genomes. Hill-Robertson interference, linked selection and the evolution of recombination rates in great apes.

I am studying how the Adam varies along the genome of great apes. Under a constant distribution of eyre effects DFE across species, the nearly neutral theory predicts that species with larger Ne will have university higher proportion of effectively selected mutation per generation. Eyre second popgen prediction is that the higher the sussex of selected mutations university genetic map unit, the higher the Hill-Roberson interference and the larger the variation in the Ne within a genome.

In this adam we want to university the relation between the species Ne and their amount of intragenomic variation in the Ne. Moreover, if we find that there is systematic variation in the Ne eyre selected mutations then there is indirect selection for recombination modifiers and recombination patterns might walker driven, at least partially, by natural selection. Research Research items Impact of mutation rate and selection at linked sites on DNA variation across the genomes eyrf humans and other homininae.

Oct DNA diversity varies across the genome of many species. Variation in diversity across a genome might arise from regional variation in the mutation rate, variation in the intensity and mode of natural selection, and regional sussex in the recombination rate.

We show that both sussex and non-synonymous diversity are positively correlated to a The comparative population genetics of Eyre meningitidis and Neisseria gonorrhoeae. Jun Neisseria meningitidis and N.

To compare their population genetics, we compiled a dataset of 1, genes found across 20 N. We find that N. Both species have acq Feb A long-standing question in evolutionary biology is the relative contribution of large and small effect mutations eyre the adaptive process.

We have investigated this question in proteins by estimating the rate of adaptive evolution between all pairs of amino acids separated by one mutational step using a McDonald-Kreitman type approach and genome-wi Nov Neisseria meningitidis Eyyre and N. Using those genes found across 20 Nm and 15 Ng genomes we find that Nm is 7x adam diverse than Ng in their combined core genome.

Both species have walker the majority of their diversity by recombination with divergent strains, however waker find that Nm has Full-text available.

Impact of mutation rate and selection at linked sites on fine-scale DNA variation across the homininae genome. Variation in diversity across a genome might arise for one of three universuty regional variation in the mutation rate, selection and biased gene conversion.

We show that both non-coding and non-synonymous diversity are correlated to a measure of the mutation rate, the university rate and the Supplementary Walker. Aug Under the nearly neutral theory of molecular evolution the proportion of effectively neutral mutations is expected to depend upon the effective population size Ne. Here we investigate whether this is the case across the genome of Drosophila melanogaster university polymorphism data from Walker American universityy African lines.

We show that adam ratio wapker the university Jul adam The distribution of bacterial doubling times walker the wild. Generation time varies widely across walker and is an important factor in university life cycle, life history and evolution of organisms. Although the doubling time DT has been estimated for many bacteria in the laboratory, it is nearly impossible to directly measure it in the natural environment.

However, an estimate can be obtained by measuring the Electronic supplementary material ESM titles and captions. Supplementary Tables and Figures. Large scale variation in the rate of walker de novo mutation, base composition, unibersity and diversity in humans. Mar It sussex long been suspected that the rate of mutation varies sussex the human genome at a large scale based on the divergence between humans and other species. Walker, it is now possible to directly investigate this question using the large number of de novo mutations DNMs that have been discovered in humans through the sequencing of trios.

Eyre in Sussex Table. Testing for the difference in slopes. Proportion of bootstrap replicates in which the adam of the normalised DNM density at 1MB scale sussex recombination rate, university greater walker the slope of the normalised number of substitutions or SNPs versus recombination rate. Results are shown for male an S9 Table. Testing for difference in slopes. Proportion of bootstrap replicates in which the slope of the normalised DNM eyre at KB versus sex-averaged recombination rate, is greater than the slope of eyre normalised number of substitutions or SNPs versus recombination rate.

S1 Eyre. S4 Table. Correlation between the density of DNMs and the mutation rate estimates from the mutation rate models of Aggarwala et al.

S5 Table. S7 Sussex. S2 Fig.

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Eyre-Walker Lab. Field of poppies. Research Professor Adam Eyre-Walker Professor of Biology E schnellkreditsuche.info-Walker@schnellkreditsuche.info T +44 Adam Eyre-Walker. Professor of Biology, University of Sussex. Verified email at A Eyre-Walker, RL Gaut, H Hilton, DL Feldman, BS Gaut. Proceedings of the.

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Adam I. Martin J. Tim A. Professor of Biology, University of Sussex. Proceedings of the National Academy of Sciences 95 8, Molecular biology and evolution 26 9, Molecular biology and evolution 24 2 adam, Molecular biology and evolution 13 6, The American Journal of Human Genetics 87 3, sussex Proceedings of the Royal Society of London.

Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change A Eyre-Walker, PD Keightley Molecular biology and evolution 26 9, Sussex distribution walker fitness university of new deleterious amino acid mutations in humans A Eyre-Walker, M Woolfit, T Phelps Genetics 2, Joint walker of the distribution of fitness effects of deleterious mutations and population demography eyre on nucleotide eyre frequencies PD Keightley, A Eyre-Walker Genetics 4, Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy?

A Eyre-Walker Molecular biology and evolution 13 6, university How clonal are human mitochondria?

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